Safety and Preliminary Efficacy Analysis of the mTOR Inhibitor Ridaforolimus in Patients With Taxane-Treated, Castration-Resistant Prostate Cancer

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• 作者：Robert J. Amato¹ ; ^{robert.amato@uth.tmc.edu} ; George Wilding² ; Glenn Bubley³ ; John Loewy⁴ ; Frank Haluska⁴ ; Mitchell E. Gross⁵
• 关键词：Combination therapy ; Disease stabilization ; Phase II ; Prostate-specific antigen ; Targeted therapy
• 刊名：Clinical Genitourinary Cancer
• 出版年：2012
• 出版时间：December, 2012
• 年：2012
• 卷：10
• 期：4
• 页码：232-238
• 全文大小：373 K

文摘

Background

Few options are available after taxane-based therapy in men with CRPC. Genetic alterations involving the mTOR pathway have been associated with CRPC development, raising the hypothesis that blocking mTOR signaling may be an effective targeted approach to treatment.

Patients and Methods

In this open-label phase II study, the mTOR inhibitor Ridaforolimus was administered at a dose of 50 mg intravenous once weekly to 38 patients with taxane-treated CRPC. The primary end point was best overall response according to modified Response Evaluation Criteria in Solid Tumors guidelines. Serum prostate-specific antigen levels were prospectively monitored as a biomarker for cancer activity.

Results

No objective responses were observed, but 18 patients (47.4 % ) had stable disease as their best response. Based on progression-free survival analysis, median time to progression with Ridaforolimus was 28 days (95 % confidence interval, 27-29). Eight patients (21.1 % ) had stable disease as their best overall prostate-specific antigen response. The median number of days from first to last dose was 109.5 days (range, 1-442 days). Ridaforolimus was generally well tolerated, with a safety profile similar to that observed in patients with advanced malignancies. The most common side effects were typically mild or moderate in severity.

Conclusions

Ridaforolimus was generally well tolerated. Treatment did not produce objective responses, but stable disease was observed in some patients with taxane-treated CRPC. Alternative treatment regimens, such as combination therapy with a taxane or in a maintenance treatment paradigm, should be considered for further evaluation in this patient population.