Role of histone acetylation in long-term neurobehavioral effects of neonatal Exposure to sevoflurane in rats
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- 作者：Min Jiaa ; 1 ; Wen-Xue Liua ; 1 ; Jiao-Jiao Yangb ; Ning Xub ; Ze-Min Xieb ; Ling-Sha Jua ; Mu-Huo Jia ; Anatoly E. Martynyukc ; d ; amartynyuk@anest.ufl.edu" class="auth_mail" title="E-mail the corresponding author ; Jian-Jun Yanga ; b ; yjyangjj@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：MS ; maternal separation ; BDNF ; brain-derived neurotrophic factor ; HDAC ; histone deacetylases ; NaB ; sodium butyrate ; Sev ; sevoflurane ; OF ; open field ; MWM ; Morris water maze ; FC ; fear conditioning ; MAP2 ; microtubule-associated protein 2 ; SDS-PAGE ; sodium dodecyl sulfate polyacrylamide gel electrophoresis ; TBST ; Tris-buffered saline and Tween 20 ; PBS ; phosphate-buffered saline ; CREB ; cyclic-AMP response element binding protein ; CBP ; CREB binding protein
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：91
- 期：Complete
- 页码：209-220
- 全文大小：3053 K
文摘
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Early life exposure to sevoflurane anesthesia deteriorates neurocognitive development.
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Neonatal sevoflurane anesthesia down-regulates hippocampal histone acetylation.
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Down-regulation of histone acetylation results in impairments of hippocampal synaptic plasticity.
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20">Sodium butyrate, an HDAC inhibitor, may represent a promising path to safer neonatal anesthesia with sevoflurane in rodents.