Early life exposure to sevoflurane anesthesia deteriorates neurocognitive development.
Neonatal sevoflurane anesthesia down-regulates hippocampal histone acetylation.
Down-regulation of histone acetylation results in impairments of hippocampal synaptic plasticity.
20">Sodium butyrate, an HDAC inhibitor, may represent a promising path to safer neonatal anesthesia with sevoflurane in rodents.