Role of HIF-1α in the hypoxia inducible expression of the thiamine transporter, SLC19A3
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- 作者：Kristy Zera ; Rebecca Sweet ; Jason Zastre ; jzastre@uga.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：HIF-1α ; hypoxia inducible factor 1 α ; THTR1 ; thiamine transporter 1 ; THTR2 ; thiamine transporter 2 ; HIF-1β ; hypoxia inducible factor 1 β ; FBS ; fetal bovine serum ; DFO ; deferoxamine mesylate ; HRE ; hypoxia responsive element ; WCL ; whole cell lysates ; PBS ; phosphate buffered saline ; SDS ; sodium dodecyl sulfate ; EDTA ; ethylenediaminetetraacetic acid ; LDHA ; lactate dehydrogenase A ; TPK1 ; thiamine pyrophosphokinase 1 ; TBS-T ; Tris buffered saline-tween 20 ; HRP ; Horseradish peroxidase ; ChIP ; Chromatin i
- 刊名：Gene
- 出版年：2016
- 出版时间：31 December 2016
- 年：2016
- 卷：595
- 期：2
- 页码：212-220
- 全文大小：910 K
文摘
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The high affinity thiamine transporter THTR2 is adaptively regulated by HIF-1α in hypoxia
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2010">HIF-1α directly binds the SLC19A3 minimal promoter region to induce expression
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Adaptive regulation of THTR2 is independent of the basal regulatory role of SP1