To
derive an a
cute TTC threshol
d, the
correlation between Allowable Daily Intakes (ADIs,
chroni
c values) an
d A
cute Re
feren
ce Doses (AR
fDs) o
f pesti
ci
des evaluate
d in the EU was investigate
d an
d their
distributions were
compare
d. The
correlation between AR
fDs an
d ADIs was signi
fi
cant (p = 0.01), but weak (r
2 = 0.051). Consequently, using this approa
ch to
derive a
cute TTC values
does not seem vali
d. There
fore, the
distributions o
f AR
fDs an
d ADIs were
compare
d dire
ctly, in or
der to extrapolate
from
chroni
c to a
cute TTC values. This
comparison ma
de
for the
combine
d Cramer stru
ctural
class II an
d III pesti
ci
des showe
d a ratio AR
fD/ADI o
f approximately 3 at the
fi
fth per
centile o
f the
distributions.
d="abspara0015">Based on these results, it is justified to propose a TTC for acute effects for Cramer III substances by multiplying the Cramer class III TTC threshold of 90 μg/person/day with a factor 3. This leads to an acute TTC threshold based on the Munro dataset for Cramer class III substances of 270 μg/person/day.