Effects of albumin and synthetic polypeptide-coated oxygenators on IL-1, IL-2, IL-6, and IL-10 in open heart surgery

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• 作者：Erdal Simsek^a ; ^{erdaldr@yahoo.com" class="auth_mail} ; Kasim Karapinar^b ; Onursal Bugra^c ; Ahmet Tulga Ulus^a ; Ali Sarigul^d
• 关键词：complement ; interleukin ; oxygenator ; systemic inflammatory response syndrome
• 刊名：Asian Journal of Surgery
• 出版年：April, 2014
• 年：2014
• 卷：37
• 期：2
• 页码：93-99
• 全文大小：450 K

文摘

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Summary

Background

In this study, we have tried to demonstrate the effects of coating style used in oxygenators on various hematologic and clinical parameters.

Materials and methods

Twenty-seven patients were included in the study, who had undergone operations because of elective coronary artery disease. Albumin-coated oxygenator was used in Group I. In Group II, a synthetic polypeptide-coated oxygenator was used. C1-inhib (complement), C3c, C4, interleukins (IL-1尾, IL2, IL-6, IL-10), and tumor necrosis factor alpha (TNF-伪) levels were examined at four different time intervals. Hemoglobin, hematocrit, leukocyte and platelet counts, drainage, and transfused blood volumes were analyzed.

Results

Albumin levels were significantly lower in Group I than those in Group II 5 minutes after the removal of the cross-clamp. Twenty-four hours after the surgery, Group I patients also had a significantly higher white blood cell count compared to Group II patients. TNF-伪 levels in Group I were always expressed in considerably higher amounts than those in Group II. IL-6 levels were significantly higher in Group I, but IL-10 levels were observed to be higher in Group II (p聽<聽0.05).

Conclusion

Synthetic polypeptide-coated advanced technology, which employed oxygenators, had an important attenuator effect on acute phase reactants and also on the inflammatory response.