Distinct roles of Eps8 in the maturation of cochlear and vestibular hair cells
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- 作者：Elisa Tavazzania ; Paolo Spaiardia ; Valeria Zampinia ; &dagger ; ; valeria.zampini@parisdescartes.fr" class="auth_mail" title="E-mail the corresponding author ; Donatella Continia ; &Dagger ; ; contini@uic.edu" class="auth_mail" title="E-mail the corresponding author ; Marco Mancaa ; Giancarlo Russoa ; Ivo Prigionia ; Walter Marcottib ; w.marcotti@sheffield.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Sergio Masettoa ; smasetto@unipv.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：AP ; action potential ; d.c. ; direct current ; EGTA ; ethylene glycol tetraacetic acid ; Eps8 ; Epidermal growth factor receptor pathway substrate 8 ; HEPES ; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid ; IHCs ; inner hair cells ; KO ; knockout ; OHCs ; outer hair cells ; P ; postnatal day ; Rm ; cell membrane input resistance ; Rs ; series resistance ; RT ; room temperature ; Vm ; voltage membrane potential ; Vrest ; resting membrane potential ; WT ; wild type
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：22 July 2016
- 年：2016
- 卷：328
- 期：Complete
- 页码：80-91
- 全文大小：2302 K
文摘
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Eps8 is required for proper stereocilia elongation in cochlear and vestibular hair cells.
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Eps8-KO vestibular hair cells, unlike cochlear inner hair cells, express their normal pattern of basolateral ion channels.
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Eps8 deletion similarly affects cochlear and vestibular hair bundles growth but impairs hearing only.