Primary Burkitt-like lymphoma of the orbit diagnosed using ultrasound-guided core needle biopsy: A case study

详细信息    查看全文

• 作者：Ahmed A. Sultan^b ; ¹ ; Joshua R. Kapp^b ; ¹ ; ^{Joshua.kapp@doctors.org.uk" class="auth_mail" title="E-mail the corresponding author} ; Waseem Jerjes^a ; Rifat Hamoudi^b ; Simon Morley^a ; Colin Hopper^a ; ^b ; ^c
• 关键词：Burkitt-like lymphoma (BLL) ; Ultrasound-guided core needle biopsy (US guided CNB)
• 刊名：Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：28
• 期：1
• 页码：36-40
• 全文大小：1581 K

文摘

Burkitt-like lymphoma, also known as (B-Cell lymphoma, Unclassifiable) is a rare extra-nodal B-cell lymphoma with features intermediate between Burkitt's lymphoma and diffuse large B-cell lymphoma.

A 73-year-old Caucasian female presented to our Emergency Department with orbital pain, deterioration of vision, nausea and vomiting. General examination revealed right orbital proptosis and reduction in visual acuity; and computed tomography confirmed the presence of a right retro-bulbar mass.

Tissue samples were obtained using ultrasound-guided core needle biopsy. An experienced head and neck radiologist (SM) undertook the procedure under general anaesthesia, using a lateral orbital approach. The instrument used was the Toshiba Aplio. The procedure was without complication. Results from histopathological, immunohistochemical and genetic analyses confirmed the diagnosis of stage IV orbital Burkitt-like lymphoma with atypical features.

Despite the ambiguity of immunohistochemistry and cytogenetic results, the patient was treated for Burkitt's lymphoma. The treatment had to be re-adjusted after two rounds of chemotherapy as the patient developed chemotherapy-induced encephalopathy. The patient remained symptom-free for 8 months. This case demonstrates the application of ultrasound-guided core needle biopsy for rapid and accurate lymphoma diagnosis and sub-classification.