HIV Broadly Neutralizing Antibodies: Taking Good Care Of The 98%

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• 作者：Devin Sok¹ ; ² ; ³ ; ⁴ ; ^{devinsok@scripps.edu" class="auth_mail" title="E-mail the corresponding author} ; Dennis R. Burton² ; ³ ; ⁴ ; ⁵ ; ^{burton@scripps.edu" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Immunity
• 出版年：2016
• 出版时间：15 November 2016
• 年：2016
• 卷：45
• 期：5
• 页码：958-960
• 全文大小：319 K

文摘

In this issue of Immunity, Huang et al. (2016) describe an exceptionally broad and potent neutralizing antibody to HIV. This antibody, N6, is capable of neutralizing up to 98% of global isolates with a potent median IC₅₀ of 0.04 μg/mL, making it the current “best-in-class” for bNAbs targeting the CD4 binding site.