CD4⁺ virtual memory: Antigen-inexperienced T cells reside in the naïve, regulatory, and memory T cell compartments at similar frequencies, implications for autoimmunity

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• 作者：Alina I. Marusina^a ; ¹ ; Yoko Ono^a ; ¹ ; Alexander A. Merleev^a ; Michiko Shimoda^a ; Hiromi Ogawa^a ; Elizabeth A. Wang^a ; Kayo Kondo^a ; Laura Olney^a ; Guillaume Luxardi^a ; Yoshinori Miyamura^a ; Tilahun D. Yilma^c ; ^d ; Itzel Bustos Villalobos^a ; Jennifer W. Bergstrom^a ; Daniel G. Kronenberg^a ; Athena M. Soulika^a ; Iannis E. Adamopoulos^b ; Emanual Maverakis^a ; ^{emaverakis@ucdavis.com}
• 关键词：Next generation sequencing ; T cell repertoire analysis ; CD4 T cell ; T regulatory cells ; Memory T cells ; Virtual memory ; Autoimmunity ; Driver T cells ; Experimental autoimmune encephalomyelitis ; Hematopoietic stem cell transplantation
• 刊名：Journal of Autoimmunity
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：77
• 期：Complete
• 页码：76-88
• 全文大小：2291 K
• 卷排序：77

文摘

Antigen-inexperienced CD4+ T cells comprise a portion of the memory repertoire. CD4+ T cells can display a memory phenotype without clonal expansion to an antigen. Our study supports the existence of CD4+ virtual memory T cells. These findings posit a new paradigm for T cell maturation.