Disease Centered Around Calcified Taenia solium Granuloma

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• 作者：Theodore E. Nash¹ ; Javier A. Bustos² ; ^{javier.bustos@jhu.edu} ; Hector H. Garcia² ; ³ ; for The Cysticercosis Working Group in Perú
• 关键词：neurocysticercosis ; calcified granuloma ; perilesional edema ; epilepsy ; seizures
• 刊名：Trends in Parasitology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：33
• 期：1
• 页码：65-73
• 全文大小：3537 K
• 卷排序：33

文摘

Taenia solium (the pork tapeworm) is present in most developing countries, where it is a frequent cause of seizures and other neurological disease. Parasitic larvae invade the human brain, establish, and eventually resolve, leaving a calcified scar. While these lesions are common in endemic regions, and most of these are clinically silent, a proportion of individuals with calcified cysticerci develop seizures from these lesions, and 30–65% of these cases are associated with perilesional edema (PE), likely due to host inflammation. This manuscript summarizes the importance, characteristics, natural history, and potential prevention and treatments of symptomatic calcified neurocysticercosis (NCC).