Butenolide derivatives from the plant endophytic fungus Aspergillus terreus

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• 作者：Feng Guo^a ; ^b ; Zhanlin Li^a ; ^b ; Xiangwei Xu^a ; ^b ; Kaibo Wang^a ; ^b ; Meili Shao^a ; ^b ; Feng Zhao^c ; ^{ytuzhaofeng@163.com" class="auth_mail" title="E-mail the corresponding author} ; Haifeng Wang^a ; ^b ; Huiming Hua^a ; ^b ; Yuehu Pei^a ; ^b ; Jiao Bai^a ; ^b ; ^{baijiao@hotmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Endophytic fungus ; Aspergillus terreus ; Butenolides ; Structure elucidation ; Anti-inflammatory activity
• 刊名：Fitoterapia
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：113
• 期：Complete
• 页码：44-50
• 全文大小：704 K

文摘

Three new butenolides containing 5-hydroxyfuran-2(5H)-one core, asperteretal A (1), asperteretal B (2), and asperteretal C (3), together with seven known butenolides (4–10), were obtained from an endophytic fungus Aspergillus terreus PR-P-2 isolated from the plant Camellia sinensis var. assamica. The structures of compounds 1–3 were elucidated on the basis of detailed spectroscopic analysis including UV, IR, HRESIMS, 1D and 2D NMR, and ECD spectra. Compounds 1, 3, 5 and 6–8 showed potent inhibitory effects on NO production in RAW 264.7 lipopolysaccharide-induced macrophages, and compounds 5 and 8 also exhibited moderate cytotoxicity against HL-60 cell line.