Polyketide butenolide, diphenyl ether, and benzophenone derivatives from the fungus Aspergillus flavipes PJ03-11

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• 作者：Li-Hua Zhang^a ; ^b ; Bao-Min Feng^c ; Yu-Qing Zhao^a ; ^b ; Yi Sun^d ; Bing Liu^a ; ^b ; Fang Liu^a ; ^b ; Gang Chen^a ; ^b ; Jiao Bai^a ; ^b ; Hui-Ming Hua^a ; ^b ; Hai-Feng Wang^a ; ^b ; ^{wanghaifeng0310@163.com" class="auth_mail" title="E-mail the corresponding author} ; Yue-Hu Pei^a ; ^b ; ^{peiyueh@vip.163.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Polyketide ; Butenolide ; Diphenyl ether ; Benzophenone ; Aspergillus flavipes ; α-Glucosidase
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2016
• 出版时间：15 January 2016
• 年：2016
• 卷：26
• 期：2
• 页码：346-350
• 全文大小：413 K

文摘

Five new polyketides including three new butenolides (1–3), one new diphenyl ether (4), and one new benzophenone (5), together with eleven known compounds (6–16) were isolated from a wetland fungus Aspergillus flavipes PJ03-11. Their structures were elucidated on the basis of detailed spectroscopic analysis. All the isolated compounds were tested for their α-glucosidase inhibitory activities. The results showed that compounds 1–3, 6, 7, 11, 15 and 16 exhibited stronger inhibitory activities than acarbose. And the preliminary structure–activity relationships of aspulvinone and diphenyl ether compounds on the α-glucosidase inhibitory activity were reported.