TAILS N-Terminomics and Proteomics Show Protein Degradation Dominates over Proteolytic Processing by Cathepsins in Pancreatic Tumors
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- 作者：Anna Prudova1 ; 5 ; Vasilena Gocheva2 ; 5 ; 8 ; Ulrich auf dem Keller1 ; 5 ; 7 ; Ulrich Eckhard1 ; 5 ; Oakley C. Olson2 ; Leila Akkari3 ; 4 ; Georgina S. Butler1 ; Nikolaus Fortelny1 ; Philipp F. Lange1 ; Jennifer C. Mark1 ; Johanna A. Joyce2 ; 3 ; 4 ; 6 ; johanna@joycelab.org" class="auth_mail" title="E-mail the corresponding author ; Christopher M. Overall1 ; 6 ; chris.overall@ubc.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：pancreatic neuroendocrine cancer ; cysteine cathepsins ; lysosomal hydrolases ; TAILS degradomics ; proteomics ; substrate discovery ; proteolytic processing ; degradation ; proteases ; ECM
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：9 August 2016
- 年：2016
- 卷：16
- 期：6
- 页码：1762-1773
- 全文大小：3353 K
文摘
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Proteomics identified substrate cleavage sites for multiple cathepsins in vivo
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The majority of cleavage products reflect protein degradative activities and roles
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Stable cleavage products from processing are enriched for extracellular proteins
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Uncovered substrates suggest regulatory mechanisms for cathepsins in cancer