Stille coupling approaches to the stereospecific synthesis of 7-[(E)-alkylidene]cephalosporins

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• 作者：Buynak ; John D. ; Doppalapudi ; Venkata Ramana ; Frotan ; Mohammed ; Kumar ; Ramon
• 关键词：Tin and compounds ; cephalosporins ; penicillins ; enzyme inhibitors
• 刊名：Tetrahedron Letters
• 出版年：1999
• 出版时间：February 12, 1999
• 年：1999
• 卷：40
• 期：7
• 页码：1281-1284
• 全文大小：204 K

文摘

Stille coupling methodology is used to stereospecifically synthesize 7-[(E)-alkylidene]cephalosporins, potential enzyme inhibitors which are unavailable via other synthetic methodology. Two procedures are described, utilizing either a stannylalkylidene cephem which is then coupled with an organohalide, or a haloalkylidene cephem which is coupled with an organostannane.