Cephalosporin-derived inhibitors of β-Lactamase. Part 4: The C3 substituent

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• 作者：Buynak ; John D. ; Vogeti ; Lakshminarayana ; Doppalapudi ; Venkata Ramana ; Solomon ; George Martin ; et. al.
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2002
• 出版时间：June 17, 2002
• 年：2002
• 卷：12
• 期：12
• 页码：1663-1666
• 全文大小：148 K

文摘

New C3-substituted β-lactamase inhibitors were prepared and evaluated against representative class A and class C enzymes. It was possible to improve simultaneous inhibitory activity of both classes of serine hydrolase. Other inhibitors showed high selectivity for either the class C cephalosporinases or the class A penicillinases. This represents the first time that cephalosporin-derived inhibitors have demonstrated selectivity for the class A β-lactamases.