Neuromagnetic evidence of impaired cortical auditory processing in pediatric intractable epilepsy

详细信息    查看全文

• 作者：Milena Korostenskaja ; Maria Pardos ; Hisako Fujiwara ; Teija Kujala ; Paul Horn ; Douglas Rose ; Anna Byars ; David Brown ; Joo Hee Seo ; Yingying Wang ; Jennifer Vannest ; Jing Xiang ; Ton DeGrauw ; Risto Nä
• 关键词：Auditory information processing ; Cognitive deficits ; Epilepsy ; Event-related potentials (ERPs) ; Magnetoencephalography (MEG) ; Mismatch negativity (MMN)
• 刊名：Epilepsy Research
• 出版年：2010
• 出版时间：November 2010
• 年：2010
• 卷：92
• 期：1
• 页码：63-73
• 全文大小：402 K

文摘

Summary

Purpose

We aimed to determine the changes in neural correlates of auditory information processing such as auditory detection, encoding, and sensory discrimination in pediatric patients with intractable epilepsy.

Methods

In this magnetoencephalography (MEG) study, 10 patients and 10 age- and gender-matched healthy controls were investigated with the multi-feature mismatch negativity (MMN) paradigm. Latencies and amplitudes of M100, M150, M200, and MMN event-related fields were evaluated.

Results

All event-related fields in response to standard stimuli (M100, M150 and M200) and responses to occasional five deviant sounds, deviating from the standard stimuli either in duration, frequency, intensity, location, or by including a silent gap were reduced in amplitude in epilepsy patients compared with healthy controls.

Conclusions

Our study suggests that auditory information processing is impaired in patients with drug-resistant epilepsy, being evident both in stimulus feature encoding (as reflected by changes of early event-related components, e.g., M100) and in cortical sound discrimination (as reflected by MMNm). The neural changes involving diminished M100 as well as MMNms for all five deviant sound types suggest wide-spread auditory information processing impairments in these patients.