Aplysia kurodai-derived glycosaminoglycans increase the phagocytic ability of macrophages via the activation of AMP-activated protein kinase and cytoskeletal reorganization in RAW264.7 cells

详细信息    查看全文

• 作者：Ji Hyeon Ryu^a ; Jina Sung^a ; Chengliang Xie^b ; Min-Kyoung Shin^c ; Chang-Woon Kim^a ; ^d ; Nam-Gil Kim^e ; Yeung Joon Choi^f ; Byeong Dai Choi^f ; Sang Soo Kang^b ; Dawon Kang^a ; ^{dawon@gnu.ac.kr}
• 关键词：AMPK ; Aplysia ; Glycosaminoglycans ; Inflammation ; Macrophage ; Phagocytosis
• 刊名：Journal of Functional Foods
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：27
• 期：Complete
• 页码：122-130
• 全文大小：1576 K
• 卷排序：27

文摘

Aplysia kurodai-derived glycosaminoglycans (GAGs) activate macrophage RAW264.7 cells. Macrophage activation increases cell size, cellular spreading, and vacuole formation. GAGs increase phagocytic ability of RAW264.7 cells. GAG-induced cellular spreading and phagocytosis are reduced by inhibition of AMPK. Disruption of cytoskeletal reorganization reduces GAG-activated phagocytic ability.