Co-expression of two heterologous lactate dehydrogenases genes in Kluyveromyces marxianus for l-lactic acid production

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• 作者：Jae Won Lee^a ; ¹ ; Jung Hoon In^a ; ¹ ; Joon-Bum Park^a ; ¹ ; Jonghyeok Shin^a ; Jin Hwan Park^b ; Bong Hyun Sung^c ; Jung-Hoon Sohn^c ; Jin-Ho Seo^d ; Jin-Byoung Park^e ; Soo Rin Kim^f ; ^{soorinkim@knu.ac.kr} ; Dae-Hyuk Kweon^a ; ^{dhkweon@skku.edu}
• 关键词：Lactic acid ; Kluyveromyces marxianus ; Lactate dehydrogenase ; Co-expression ; Optimal pH
• 刊名：Journal of Biotechnology
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：241
• 期：Complete
• 页码：81-86
• 全文大小：1938 K
• 卷排序：241

文摘

Genes encoding LDHs were randomly integrated in K. marxianus genome. K. marxianus expressing heterologous LDHs efficiently produced lactic acid. Co-expression of LDHs with different pH optima enhanced LA production.