Association between common genetic variants of ¦Á2A-, ¦Á2B-, and ¦Á2C-adrenergic receptors and ischemic stroke

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• 作者：Seung-Hun Oh^a ; ¹ ; ^{ohsh72@chamc.co.kr} ; Kyung-Tae Min^b ; ² ; ^{sea5290@naver.com} ; Young-Joo Jeon^b ; ³ ; ^{white0885@naver.com} ; Mi-Hwa Kim^a ; ⁴ ; ^{meiha@chamc.co.kr} ; Ok-Joon Kim^a ; ⁵ ; ^{okjun77@cha.ac.kr} ; Byoung-Soo Shin^c ; ⁶ ; ^{sbsoo@chonbuk.ac.kr} ; Doyeun Oh^b ; ⁷ ; ^{doh@cha.ac.kr} ; Nam-Keun Kim^b ; ^{nkkim@cha.ac.kr}
• 关键词：Adrenergic receptor ¦Á2 ; Polymorphism ; ADRA2B gene ; Ischemic stroke ; Small-vessel disease
• 刊名：Clinical Neurology and Neurosurgery
• 出版年：2013
• 出版时间：January, 2013
• 年：2013
• 卷：115
• 期：1
• 页码：26-31
• 全文大小：214 K

文摘

Background

The alpha2-adrenergic receptor (¦Á2-AR) mediates physiological responses to endogenous catecholamine, and genetic variants of ¦Á2-AR may predispose to clinical vascular diseases. We evaluated whether common genetic variants of each three subtype of alpha2-adrenergic receptor (ADRA2A, ADRA2B, and ADRA2C) were associated with ischemic stroke.

Methods

A total of 616 patients with ischemic stroke and 512 controls were genotyped for the ADRA2A 1780G>A, ADRA2B 301-303 I/D, and ADRA2C 322-325 I/D polymorphisms. Logistic regression analyses, adjusting for multiple comparisons, were used to determine the association between the minor allele of each of three ADRA2 genes and the risk of ischemic stroke and pathophysiological subtypes.

Results

The ADRA2B 301-303 D allele was more prevalent in the stroke group, compared to controls (DD vs. II, OR: 1.78, 95 % CI: 1.18-2.69; recessive, OR: 1.55, 95 % CI: 1.06-2.26). A subgroup analysis revealed that this association was found only in the small vessel diseases (SVD) type (DD vs. II, OR: 1.92, 95 % CI: 1.11-3.33). The ADRA2A and ADRA2C polymorphisms did not contribute to an increased risk of ischemic stroke or any pathophysiological subtype.

Conclusions

The ADRA2B 301-303 D allele confers an increased risk of overall ischemic stroke and SVD subtype.