Impact of Female Gender on Bleeding Complications After Transradial Coronary Intervention (from the Korean Transradial Coronary Intervention Registry)

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• 作者：Jeoung-Sook Shin ; MD^a ; Seung-Jea Tahk ; MD ; PhD^a ; Hyoung-Mo Yang ; MD ; PhD^a ; ^{yhhm20@hanmail.net" class="auth_mail} ; Myeong-Ho Yoon ; MD ; PhD^a ; So-Yeon Choi ; MD ; PhD^a ; Byoung-Joo Choi ; MD^a ; Hong-Seok Lim ; MD ; PhD^a ; You-Hong Lee ; MD^a ; Kyoung-Woo Seo ; MD^a ; Se-Jun Park ; MD^a ; Yong-Woo Choi ; MD^a ; Junghan Yoon ; MD^b ; Young Jin Youn ; MD^b ; Byung Ryeol Cho ; MD^c ; Kwang Soo Cha ; MD ; PhD^d ; Kyoo Rok Han ; MD^e ; Min Su Hyon ; MD^f ; Seung Woon Rha ; MD^g ; Byung Ok Kim ; MD^h ; Won Yong Shin ; MDⁱ ; Keum Soo Park ; MD^j ; Sang Sig Cheong ; MD^k ; Myung Ho Jeong ; MD ; PhD^l
• 刊名：The American Journal of Cardiology
• 出版年：15 June 2014
• 年：2014
• 卷：113
• 期：12
• 页码：2002-2006
• 全文大小：287 K

文摘

Besides poor clinical outcomes, female gender has been known as a high-risk factor for bleeding complications. This study aimed to investigate the impact of gender on clinical outcomes and bleeding complications after transradial coronary intervention (TRI). The Korean TRI registry is a retrospective multicenter registry with 4,890 patients who underwent percutaneous coronary intervention in 2009 at 12 centers. To compare clinical outcomes and bleeding complications between the male and female groups, we performed a propensity score matching in patients who received TRI. A total of 1,194 patients (597 in each group) were studied. The primary outcome was 1-year major adverse cardiac events, including all-cause mortality, myocardial infarction, target vessel revascularization, and stroke. The secondary outcome was major bleeding (composite of bleeding requiring transfusion of ≥2 units of packed cells or bleeding that was fatal). The proportion of major adverse cardiac events was similar between the 2 groups (6.2% vs 4.7%, p = 0.308). The female group had a greater incidence of major bleeding (0.3% vs 3.2%, p <0.001). On multivariate analysis, female gender (odds ratio [OR] 7.748, 95% confidence interval [CI] 1.767 to 13.399), age ≥75 years (OR 5.824, 95% CI 2.085 to 16.274), and chronic kidney disease (OR 7.264, 95% CI 2.369 to 12.276) were independent predictors of major bleeding. In conclusion, the female gender had a tendency for more bleeding complications than male gender after TRI without difference in the clinical outcome.