Supplemented vaccination with tandem repeat M2e virus-like particles enhances protection against homologous and heterologous HPAI H5 viruses in chickens
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- 作者：Byung-Min Song ; Hyun-Mi Kang ; Eun-Kyoung Lee ; Suk Chan Jung ; Min-Chul Kim ; Yu-Na Lee ; Sang-Moo Kang ; Youn-Jeong Lee ; leeyj700@korea.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Highly pathogenic avian influenza ; M2e5x virus-like particles ; Supplemented vaccine ; Chicken
- 刊名：Vaccine
- 出版年：2016
- 出版时间：27 January 2016
- 年：2016
- 卷：34
- 期：5
- 页码：678-686
- 全文大小：2131 K
文摘
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HA-based vaccines provide limited cross-protection against novel influenza virus.
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The M2e-based vaccine is considered universal candidate against influenza virus.
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M2e5x VLPs induce M2e-specific antibodies, but not provide protection.
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Supplementation with M2e5x VLPs provide good protection against HPAI H5 viruses.