Active Control of Repetitive Structural Transitions between Replication Forks and Holliday Junctions by Werner Syndrome Helicase
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- 作者：Soochul Shin1 ; 2 ; 3 ; Jinwoo Lee1 ; 2 ; 3 ; Sangwoon Yoo1 ; 2 ; 3 ; Tomasz Kulikowicz5 ; Vilhelm A. Bohr5 ; Byungchan Ahn6 ; bbccahn@mail.ulsan.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Sungchul Hohng1 ; 2 ; 3 ; 4 ; shohng@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：werner syndrome helicase ; single-molecule FRET ; replication fork regression
- 刊名：Structure
- 出版年：2016
- 出版时间：2 August 2016
- 年：2016
- 卷：24
- 期：8
- 页码：1292-1300
- 全文大小：1612 K
文摘
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The fork regression of WRN is readily activated after lagging arm unwinding
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WRN migrates a Holliday junction with 3.2 ± 0.03 bases/s velocity
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WRN reverses branch migration direction at short heterologous sequences
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The branch migration reversal of WRN is an active process