Syntheses, biological activities and SAR studies of novel carboxamide compounds containing piperazine and arylsulfonyl moieties
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- 作者：Bao-Lei Wanga ; Yan-Xia Shib ; Shu-Jun Zhanga ; Yi Maa ; Hong-Xue Wanga ; Li-Yuan Zhanga ; Wei Weia ; Xing-Hai Liua ; Yong-Hong Lia ; Zheng-Ming Lia ; nkzml@vip.163.com" class="auth_mail" title="E-mail the corresponding author ; Bao-Ju Lib ; libj@mail.caas.net.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Piperazine derivatives ; Arylsulfonyl group ; Biological activities ; 3D-QSAR ; Theoretical calculation
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：19 July 2016
- 年：2016
- 卷：117
- 期：Complete
- 页码：167-178
- 全文大小：1284 K
文摘
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24 novel piperazine-containing carboxamide compounds were synthesized.
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Several compounds showed significant antifungal activities.
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Several compounds exhibited good herbicidal and KARI inhibitory activities.
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3D-QSAR study and theoretical calculation of these compounds were carried out.