The identification of a series of novel, soluble non-peptidic neuropeptide Y Y2 receptor antagonists
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- 作者：Gillian E. Lunniss ; Ashley A. Barnes ; Nick Barton ; Matteo Biagetti ; Federica Bianchi ; Stephen M. Blowers ; Laura L. Caberlotto ; Am ; a Emmons ; Ian P. Holmes ; Dino Montanari ; Roz Norris ; Gemma V. Puckey
- 关键词：NPY antagonist ; NPY Y2 antagonist ; NPY ; NPY Y2
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2010
- 出版时间：15 December 2010
- 年：2010
- 卷：20
- 期：24
- 页码：7341-7344
- 全文大小：678 K
文摘
The identification and subsequent optimisation of a selective non-peptidic NPY Y2 antagonist series is described. This led to the development of amine 2, a selective, soluble NPY Y2 receptor antagonist with enhanced CNS exposure.