Influence of MTHFR polymorphisms on cardiovascular risk markers in elite athletes

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• 作者：Monica Currò ; ¹ ; ^{monica.curro@unime.it" class="auth_mail" title="E-mail the corresponding author} ; Debora Di Mauro¹ ; ^{ddimauro@unime.it" class="auth_mail" title="E-mail the corresponding author} ; Daniele Bruschetta ^{daniele.bruschetta@unime.it" class="auth_mail" title="E-mail the corresponding author} ; Federico D'Amico ^{fededamico92@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Mercurio Vecchio ^{mercuriovecchio@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Fabio Trimarchi ^{fatrim@unime.it" class="auth_mail" title="E-mail the corresponding author} ; Riccardo Ientile ; ^{ientile@unime.it" class="auth_mail" title="E-mail the corresponding author} ; Daniela Caccamo ^{dcaccamo@unime.it" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Elite athletes ; Cardiovascular risk ; Homocysteine ; Advanced oxidation protein products ; Gene polymorphisms
• 刊名：Clinical Biochemistry
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：49
• 期：1-2
• 页码：183-185
• 全文大小：217 K

文摘

<dl class="listitem" id="list_l0005"><dt class="label">•dt><dd>

d="p0190">MTHFR and PON1 polymorphisms modulate plasma levels of homocysteine and oxidated proteins, respectively.

dd><dt class="label">•dt><dd>

d="p0195">The highest Hcy plasma levels, together with the lowest folates, were observed in MTHFR TT677/AA1298 subjects in both groups.

dd><dt class="label">•dt><dd>

d="p0200">Growing AOPP plasma concentrations were observed in hurdlers with either MTHFR CT677/AC1298 or TT677/AA1298 diplotypes.

dd><dt class="label">•dt><dd>

d="p0205">AOPP were positively correlated with Hcy, and both markers were positively dependent on MTHFR genotype in hurdlers.

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