Sodium butyrate attenuates soybean oil-based lipid emulsion-induced increase in intestinal permeability of lipopolysaccharide by modulation of P-glycoprotein in Caco-2 cells

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• 作者：Jun-Kai Yan^a ; ^b ; Zi-Zhen Gong^a ; ^b ; Tian Zhang^a ; ^b ; Wei Cai^a ; ^b ; ^{caiw204@sina.com}
• 关键词：Sodium butyrate ; P-glycoprotein ; Lipopolysaccharide ; Caco-2 ; Soybean oil-based lipid emulsion ; Parenteral nutrition
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：791-795
• 全文大小：825 K
• 卷排序：482

文摘

Caco-2 cells were used as models for studying parenteral nutrition in vitro. NaBut restored SOLE-induced down-regulation of P-gp in Caco-2 cells. Regulation of P-gp by NaBut was mediated via nuclear recruitment of FOXO 3a. NaBut modulated the permeability of LPS by P-gp function, not barrier function.