Tannase enhances the anti-inflammatory effect of grape pomace in Caco-2 cells treated with IL-1β

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• 作者：Isabela M. Martins^a ; ^b ; ^{mmartins.isabela@gmail.com} ; Gabriela A. Macedo^a ; ^{macedoga@gmail.com} ; Juliana A. Macedo^a ; ^{jumacedo@gmail.com} ; Bruna S. Roberto^a ; ^{bruna_sampaio@ymail.com} ; Qianru Chen^b ; ^{qianru.chen@outlook.com} ; Jeffrey B. Blumberg^b ; ^{jeffrey.blumberg@tufts.edu} ; Chung-Yen Oliver Chen^b ; ^{oliver.chen@tufts.edu}
• 关键词：Grape pomace ; Tannase ; Phenolic compounds ; Caco-2 cells ; Gut inflammation
• 刊名：Journal of Functional Foods
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：29
• 期：Complete
• 页码：69-76
• 全文大小：560 K
• 卷排序：29

文摘

Tannase treatment liberates monomeric polyphenolics and aglycones of grape pomace. Tannase treatment enhances antioxidant activity of grape pomace. Grape pomace and tannase treated grape pomace attenuate IL-8 and PGE2 secretions. Grape pomace and tannase treated grape pomace inhibit IL-1β-induced NF-κB activation. Tannase treatment increases anti-inflammatory actions of grape pomace in Caco-2 cells.