Chronic stress is associated with reduced circulating hematopoietic progenitor cell number: A maternal caregiving model

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• 作者：Kirstin Aschbacher^a ; ^b ; ^{kirstin.aschbacher@ucsf.edu} ; Jeffrey M. Milush^c ; Amanda Gilbert^a ; Carlos Almeida^a ; Elizabeth Sinclair^c ; Lorrie Epling^c ; S. Marlene Grenon^d ; ^e ; ^f ; Elysa J. Marco^g ; Eli Puterman^h ; Elissa Epel^a
• 关键词：Endothelial progenitor cells (EPCs) ; Circulating angiogenic cells (CACs) ; Monocytes ; Cardiovascular risk ; Preclinical atherosclerosis ; Cholesterol ; Chronic stress ; Maternal caregiving ; Family interactions ; Autism
• 刊名：Brain, Behavior, and Immunity
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：59
• 期：Complete
• 页码：245-252
• 全文大小：486 K
• 卷排序：59

文摘

Circulating hematopoietic progenitor cells (CPCs) are CD34+KDR+ and CD133+KDR+. Low CPCs prospectively predict cardiovascular events in meta-analyses. Chronic stress of maternal caregiving is associated with reduced CPCs. Negative daily maternal-child interactions explain this stress-immune relationship. As expected, low CPCs are associated with a poorer lipid profile in this sample.