Cord Blood Units with High CD3+ Cell Counts Predict Early Lymphocyte Recovery After In Vivo T Cell-Depleted Single Cord Blood Transplantation
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- 作者：Nerea Castillo1 ; ncastillo@bst.cat" class="auth_mail" title="E-mail the corresponding author ; Irene Garcí ; a-Cadenas2 ; Cristina Dí ; az-Heredia3 ; Rodrigo Martino2 ; Pere Barba4 ; Christelle Ferrà ; 5 ; Carme Canals1 ; Izaskun Elorza3 ; Teresa Olivé ; 3 ; Isabel Badell6 ; Jorge Sierra2 ; David Valcá ; rcel4 ; Sergio Querol1
- 关键词：Lymphocyte recovery ; T cell depletion ; Umbilical cord blood transplantation
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：22
- 期：6
- 页码：1073-1079
- 全文大小：480 K
文摘
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We studied predictive factors for lymphocyte recovery after single umbilical cord blood transplantation.
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We analyzed the impact on outcomes of absolute lymphocyte count on day 42 after single umbilical cord blood transplantation.
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We report 3 different factors influencing lymphocyte recovery after cord blood transplantation: infused CD3+ cell counts, ATG dose, and HLA mismatch degree.
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We found an association between higher ALC42 level and improved nonrelapse mortality and survival.
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Infusion of a high number of CD3+ cells, administration of low ATG dose in conditioning regimens, and the use of better HLA-matched CBUs may help improve outcomes after umbilical cord blood transplantation.