Concurrent administration of diethylhexyl phthalate reduces the threshold dose at which bisphenol A disrupts blastocyst implantation and cadherins in mice

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• 作者：Evan D. Borman^a ; Warren G. Foster^b ; Denys deCatanzaro^a ; ^{decatanz@mcmaster.ca}
• 关键词：BPA ; DEHP ; Implantation ; Cadherins ; Uterus ; Blastocyst
• 刊名：Environmental Toxicology and Pharmacology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：49
• 期：Complete
• 页码：105-111
• 全文大小：2154 K
• 卷排序：49

文摘

We examined individual and combined administration of DEHP and BPA. Both can impede implantation in fertilized females, but dose-response curves differ. DEHP or BPA doses that are insufficient on their own have an effect in combination. Uterine e-cadherin is disrupted in conjunction with implantation failure. Cadherin-11 was disrupted in females that received BPA.