N-Cadherin and Fibroblast Growth Factor Receptors crosstalk in the control of developmental and cancer cell migrations

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• 作者：Thao Nguyen ; René ; Marc Mè ; ge ; ^{rene-marc.mege@ijm.fr" class="auth_mail" title="E-mail the corresponding author} ; ^{rene.marc.mege@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：AJ ; adherens junction ; CAFs ; cancer-associated fibroblasts ; CNS ; central nervous system ; DN ; dominant negative ; EGF ; epidermal growth factor ; EGFR ; epidermal growth factor receptor ; EMT ; epithelial to mesenchymal transition ; FA ; focal adhesion ; FGF ; fibroblast growth factor ; FGFR ; fibroblast growth factor receptor ; FRS2a ; FGFR substrate 2a ; GC ; granulosa cell ; GF ; growth factor ; KD ; kinase death ; mEpiSC ; mouse epiblast stem cell ; ROSE ; ovarian surface epithelial cell ; RTK ; receptors tyrosine kin
• 刊名：European Journal of Cell Biology
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：95
• 期：11
• 页码：415-426
• 全文大小：1164 K

文摘

Cell migrations are diverse. They constitutemajor morphogenetic driving forces during embryogenesis, but they contribute also to the loss of tissue homeostasis and cancer growth. Capabilities of cells to migrate as single cells or as collectives are controlled by internal and external signalling, leading to the reorganisation of their cytoskeleton as well as by the rebalancing of cell-matrix and cell-cell adhesions. Among the genes altered in numerous cancers, cadherins and growth factor receptors are of particular interest for cell migration regulation. In particular, cadherins such as N-cadherin and a class of growth factor receptors, namely FGFRs cooperate to regulate embryonic and cancer cell behaviours. In this review, we discuss on reciprocal crosstalk between N-cadherin and FGFRs during cell migration. Finally, we aim at clarifying the synergy between N-cadherin and FGFR signalling that ensure cellular reorganization during cell movements, mainly during cancer cell migration and metastasis but also during developmental processes.