Predictors of recurrence in Sydenham’s chorea: Clinical observation from a single center

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• 作者：Esra Gurkas ; ^{esragurkas@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Zeynep S. Karalok ; Birce D. Taskin ; Ummu Aydogmus ; Alev Guven ; Aydan Degerliyurt ; Omer Bektas ; Cahide Yilmaz
• 关键词：Sydenham&rsquo ; s chorea ; Rheumatic fever ; Recurrence
• 刊名：Brain and Development
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：38
• 期：9
• 页码：827-834
• 全文大小：225 K

文摘

Sydenham’s chorea is the most common cause of acquired chorea in children and is the major manifestation for acute rheumatic fever. Despite being known as a benign, self-limiting condition, recurrences and persistence of symptoms can be seen. In this study, we aimed to evaluate retrospectively the clinical and laboratory features of patients with Sydenham’s chorea and the rate and the course of recurrences, and to assess the risk of recurrences.

Methods

The study was a retrospective study conducted in a tertiary hospital. Patients with Sydenham’s chorea who were admitted to our outpatient clinics between January 2013 and June 2015 were included. Both newly diagnosed and follow-up patients were enrolled during this period. We retrospectively reviewed the medical charts of the patients.

Results

There were 90 patients with female predominance. The mean age of onset was 11 ± 2.4 years. Complete remission was maintained in 77 patients (85.6%) at 1–6 months and 4 patients had symptoms at more than 12 months. Patients were followed for 6 months to 9 years. The recurrence rate was 16%. When we compared recurrent patients with the non-recurrent group, complete remission in 6 months, the presence of persistent chorea, and regular use of prophylaxis were significantly different between the 2 groups.

Conclusions

Sydenham’s chorea is still an important health problem and has high morbidity in patients with recurrent and persistent chorea. The irregular usage of antibiotic prophylaxis, failure to achieve remission within 6 months, and prolongation of symptoms for more than 1 year are risk factors for recurrence of chorea.