Dioscin enhances methotrexate absorption by down-regulating MDR1 in vitro and in vivo
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- 作者：Lijuan Wanga ; jlwang1979@163.com" class="auth_mail ; Changyuan Wanga ; b ; wangcyuan@163.com" class="auth_mail ; Jinyong Penga ; b ; jinyongpeng2005@163.com" class="auth_mail ; Qi Liua ; b ; llaqii@yahoo.com.cn" class="auth_mail ; Qiang Menga ; b ; mengq531@yahoo.cn" class="auth_mail ; Huijun Suna ; b ; sunhuijun@hotmail.com" class="auth_mail ; Xiaokui Huoa ; b ; huoxiaokui@163.com" class="auth_mail ; Pengyuan Suna ; b ; spfar1004@gmail.com" class="auth_mail ; Xiaobo Yanga ; b ; bocai789770@163.com" class="auth_mail ; Yuhong Zhena ; b ; zhenyhwaner@yahoo.com.cn" class="auth_mail ; Kexin Liua ; b ; kexinliu@dlmedu.edu.cn" class="auth_mail
- 关键词：ABC ; ATP-binding cassette ; Caco-2 cells ; human colon adenocarcinoma cells ; MDR ; multidrug resistance ; MDR1 ; multidrug resistance 1 ; MTT ; 3-(4 ; 5-dimethylthiazol-2-yl)-2 ; 5-diphenyltetrazolium bromide ; MTX ; methotrexate ; ADR ; adriamycin ; Ver ; verapamil ; Rif ; rifampicin ; TEER ; trans-epithelial electrical resistance ; a  ; &rarr ;   ; b ; apical-to-basolateral ; b  ; &rarr ;   ; a ; basolateral-to-apical ; Papp ; apparent permeability coefficients ; KRB ; Krebs-Ringer buffer ; LC&ndash ; MS/MS ; liquid chrom
- 刊名：Toxicology and Applied Pharmacology
- 出版年：1 June 2014
- 年：2014
- 卷：277
- 期：2
- 页码：146-154
- 全文大小：1654 K
文摘
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Dioscin raised MTX concentration by inhibiting MDR1 in Caco-2 cells.
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Dioscin suppresses MDR1 by inhibiting NF-魏B signaling pathway in Caco-2 cells.
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Dioscin can enhance MTX absorption via inhibiting MDR1 in vivo and in vitro.
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Dioscin did not increase MTX-induced gastrointestinal mucosal toxicity.