Factors secreted from dental pulp stem cells show multifaceted benefits for treating experimental rheumatoid arthritis
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- 作者：Jun Ishikawaa ; Nobunori Takahashib ; Takuya Matsumotob ; Yutaka Yoshiokab ; Noriyuki Yamamotoa ; Masaya Nishikawaa ; Hideharu Hibia ; Naoki Ishigrob ; Minoru Uedaa ; Koichi Furukawac ; Akihito Yamamotoa ; akihito@med.nagoya-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Dental pulp stem cells ; Conditioned medium ; Macrophages ; Osteoclasts ; Rheumatoid arthritis ; Inflammation
- 刊名：Bone
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：83
- 期：Complete
- 页码：210-219
- 全文大小：2545 K
文摘
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A single intravenous administration of SHED-CM into CAIA markedly improved the arthritis symptoms and joint destruction.
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The efficacy of SHED-CM was associated with an induction of M2 macrophages and the abrogation of RANKL expression.
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SHED-CM inhibited the RANKL-induced osteoclastogenesis in vitro.
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SHED-CM specifically depleted of ED-Siglec-9 exhibited failed to induce M2 and attenuate CAIA.