A single intravenous administration of SHED-CM into CAIA markedly improved the arthritis symptoms and joint destruction.
The efficacy of SHED-CM was associated with an induction of M2 macrophages and the abrogation of RANKL expression.
SHED-CM inhibited the RANKL-induced osteoclastogenesis in vitro.
SHED-CM specifically depleted of ED-Siglec-9 exhibited failed to induce M2 and attenuate CAIA.