Feasibility of cytological specimens for ALK fusion detection in patients with advanced NSCLC using the method of RT-PCR
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- 作者：Yan Wanga ; 1 ; Yu Liuc ; 1 ; Chao Zhaob ; 1 ; Xuefei Lib ; Chunyan Wud ; Likun Houd ; Shijia Zhanga ; Tao Jianga ; Xiaoxia Chena ; Chunxia Sua ; Guanghui Gaoa ; Wei Lia ; Fengying Wua ; Aiwu Lia ; Shengxiang Rena ; harry_ren@126.com" class="auth_mail" title="E-mail the corresponding author ; Caicun Zhoua ; caicunzhoudr@163.com" class="auth_mail" title="E-mail the corresponding author ; Jun Zhange
- 关键词：NSCLC ; ALK ; Cytological specimens ; RT-PCR ; Crizotinib
- 刊名：Lung Cancer
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：94
- 期：Complete
- 页码：28-34
- 全文大小：929 K
文摘
1274 advanced NSCLC patients with cytological specimens or tumor tissue had their ALK fusion status detected by the method of RT-PCR.
The average concentration of RNA extracted from specimens and the incidence of ALK fusion were similar between cytology and tissue group.
Patients detected with cytological specimens had a similar response to ALK inhibitor as those with tissue.
Cytological specimens could be regarded as alternative samples for ALK fusion detection by the method of RT-PCR in patients with advanced NSCLC.