Nanoscale Architecture of the Axon Initial Segment Reveals an Organized and Robust Scaffold
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- 作者：Christophe Leterrier<sup>1sup><sup> ; sup><sup>christophe.leterrier@univ-amu.fr" class="auth_mail" title="E-mail the corresponding authorsup> ; Jean Potier<sup>1sup> ; Ghislaine Caillol<sup>1sup> ; Claire Debarnot<sup>1sup> ; Fanny Rueda Boroni<sup>1sup> ; Bé ; né ; dicte Dargent<sup>1sup>
- 关键词：axon initial segment ; cytoskeleton ; scaffold ; ankyrin G ; super-resolution microscopy
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：29 December 2015
- 年：2015
- 卷：13
- 期：12
- 页码：2781-2793
- 全文大小：7916 K
文摘
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The AIS nanoscale architecture was determined with super-resolution microscopy
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Head-to-head ßIV-spectrins connect actin rings to form a periodic submembrane complex
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Ankyrin G C-terminal tail extends ∼30 nm below the submembrane complex
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This organized architecture is resistant to cytoskeleton perturbations