In vivo anti-inflammatory and in vitro antioxidant activities of Mediterranean dietary plants

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• 作者：Filomena Conforti ; Silvio Sosa ; Mariangela Marrelli ; Federica Menichini ; Giancarlo A. Statti ; Dimitar Uzunov ; Aurelia Tubaro ; Francesco Menichini ; Roberto Della Loggia
• 关键词：Anti-inflammatory activity ; Antioxidant activity ; Flavonoid content ; Phenolic content ; Radical scavenging activity ; Sterols composition
• 刊名：Journal of Ethnopharmacology
• 出版年：2008
• 出版时间：28 February 2008
• 年：2008
• 卷：116
• 期：1
• 页码：144-151
• 全文大小：162 K

文摘

Five hydroalcoholic extracts of edible plants from Calabria region (Italy) used in local traditional medicine for the treatment of inflammatory diseases were evaluated for their in vivo topical anti-inflammatory activity (inhibition of croton oil-induced ear oedema in mice) and in vitro antioxidant and antiradical properties (inhibition of linoleic acid oxidation and bovine brain liposomes peroxidation, DPPH radical scavenging). All the extracts showed an anti-inflammatory effect: 300 bc;g/cm² provoked oedema reductions ranging from 21 to 27 % . All the extracts exerted also radical scavenging and/or antioxidant properties, the most active plant being Mentha aquatica L. (Lamiaceae) which contained the highest amount of phenolics (337 mg/g) and of flavonoids (15.75 mg/g). Moreover, the content and the composition of sterols were assessed by GC–MS in the examined plants Borago officinalis L. (Boraginaceae) contained the highest number of sterols.