Alpha-synuclein aggregates are excluded from calbindin-D28k-positive neurons in dementia with Lewy bodies and a unilateral rotenone mouse model

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• 作者：Alexandre N. Rcom-H'cheo-Gauthier ; Amelia Davis ; Adrian C.B. Meedeniya ; Dean L. Pountney ; ^{d.pountney@griffith.edu.au}
• 关键词：Alpha-synuclein ; Parkinson's disease ; Dementia with Lewy Bodies ; Calcium ; Calbindin-D28k ; Neurodegeneration ; Oxidative stress
• 刊名：Molecular and Cellular Neuroscience
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：77
• 期：Complete
• 页码：65-75
• 全文大小：2196 K
• 卷排序：77

文摘

Calbindin-D28k cells increased in mouse model and DLB brain tissue. Alpha-synuclein aggregates not present in calbindin-D28k expressing cells. Increased calbindin-D28K cells and expression in aged compared to young mouse model Calbindin-D28k may protect against alpha-synuclein aggregation and cell loss.