Computational modeling of spike generation in serotonergic neurons of the dorsal raphe nucleus
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- 作者：Henry C. Tuckwella ; b ; Henry.Tuckwell@Adelaide.edu.au" class="auth_mail ; tuckwell@mis.mpg.de" class="auth_mail ; Nicholas J. Peningtonc ; d
- 关键词：5-HT ; 5-hydroxytryptamine (serotonin) ; 5-HTP ; 5-hydroxytryptophan ; ACh ; acetylcholine ; AHP ; afterhyperpolarization ; BK ; big potassium channel ; Cai ; internal calcium ion concentration ; CB ; calbindin-D28k ; CBP ; calcium binding protein ; CDI ; calcium-dependent inactivation ; CNS ; central nervous syytem ; CR ; calretinin ; CRF ; corticotropin releasing factor ; CSF ; calcium source factor ; D ; duration (of spike) ; DA ; dopamine ; DRN ; dorsal raphe nucleus ; EC50 ; concentration of drug causing half-maximal respo
- 刊名：Progress in Neurobiology
- 出版年：July 2014
- 年：2014
- 卷：118
- 期：Complete
- 页码：59-101
- 全文大小：4229 K
文摘
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A computational model for 5-HT neurons of dorsal raphe nucleus is developed.
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Included are 11 ionic currents and calcium dynamics.
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Pacemaking is found to occur both with and without applied currents.
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The voltage trajectories are similar to those experimentally obtained.
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Many properties are considered including noradrenergic excitation via a1 receptors.