Theophylline, a methylxanthine drug induces osteopenia and alters calciotropic hormones, and prophylactic vitamin D treatment protects against these changes in rats
详细信息 查看全文
- 作者：Subhashis Pala ; Kainat Khana ; Shyamsundar Pal Chinaa ; Monika Mittala ; Konica porwala ; Richa Shrivastavab ; Isha Tanejac ; Zakir Hossainc ; Dhanaraju Mandalapud ; Jiaur R. Gayenc ; Muhammad Wahajuddinc ; Vishnu Lal Sharmad ; Arun K. Trivedie ; Sabyasachi Sanyale ; Smrati Bhadauriab ; Madan M. Godbolef ; Sushil K. Guptaf ; Naibedya Chattopadhyaya ; n_chattopadhyay@cdri.res.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：25-Hydoxylase ; Fibroblast growth factor-23 ; Receptor&ndash ; activator of nuclear factor kappa B ligand ; Micro-computed tomography ; Biomechanical strength ; Fracture healing
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：295
- 期：Complete
- 页码：12-25
- 全文大小：2108 K
文摘
- •
Theophylline induced osteoblast apoptosis by cAMP-induced ROS generation.
- •
Theophylline levels in bone marrow were much higher than blood.
- •
Theophylline diminished bone regeneration at the fracture site and caused osteopenia.
- •
Theophylline caused hypo-vitaminosis D, and altered calciotropic hormones.
- •
Vitamin D treatment prevented theophylline-induced changes in bone metabolism.