Low vitamin D3 and high anti-Müllerian hormone serum levels in the polycystic ovary syndrome (PCOS): Is there a link?

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• 作者：Hé ; lè ; ne Cappy^a ; Paolo Giacobini^b ; Pascal Pigny^c ; Aude Bruyneel^a ; Maryse Leroy-Billiard^a ; Didier Dewailly^a ; Sophie Catteau-Jonard^a ; ^b ; ^{sophie.jonard@chru-lille.fr" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Anti-Mü ; llerian Hormone ; Vitamin D ; Polycystic ovaries ; Infertility ; Waist circumference
• 刊名：Annales d'Endocrinologie
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：77
• 期：5
• 页码：593-599
• 全文大小：654 K

文摘

Low vitamin D serum level has been reported in women with polycystic ovary syndrome (PCOS) compared to controls. A few in vitro studies showed that the bioactive form of vitamin D is able to modulate the expression of the anti-Müllerian hormone (AMH) gene. However, in vivo studies failed to demonstrate clearly whether low vitamin D3 serum level is involved in the AMH excess of PCOS. This prospective study evaluates serum vitamin D3 and AMH levels in women with PCOS and in controls, before and after vitamin D supplementation.

Materials and methods

Among vitamin D deficient patients, 23 patients with PCOS were compared to 27 women with normal ovarian reserve (NOR). The vitamin D deficient patients received a vitamin D supplementation according to the depth of their insufficiency. For the 23 patients with PCOS and the 27 controls, serum AMH assay and serum calciotropic hormone assays [25-hydroxyvitamin D (25[OH]D), 1,25 dihydroxyvitamin D (1,25[OH]₂D) and parathyroid hormone (PTH)] were performed before and after supplementation.

Results

Serum 25(OH)D levels before treatment were statistically lower in PCOS women than in NOR patients (P < 0.05), even after adjustment for BMI, age and AMH level, but not after adjustment for waist circumference measurement. No difference in the serum AMH levels before and after treatment was observed neither in PCOS patients nor in NOR patients. In both groups, 25(OH)D serum levels were not related to serum AMH levels, serum 1,25(OH)₂D and serum PTH levels, before and after treatment.

Conclusion

We found no evidence that serum calciotropic hormones are linked to circulating AMH levels, particularly in PCOS.