Cardiovascular effects of exogenous adrenomedullin and CGRP in Ramp and Calcrl deficient mice

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• 作者：J.B. Pawlak^a ; S.E. Wetzel-Strong^a ; M.K. Dunn^b ; K.M. Caron^a ; ^{kathleen_caron@med.unc.edu}
• 关键词：AM ; adrenomedullin ; CGRP ; calcitonin gene-related peptide ; CLR ; calcitonin receptor-like receptor protein ; Calcrl ; calcitonin receptor-like receptor gene ; MAP ; mean arterial pressure ; RAMP ; receptor activity modifying protein ; dKO ; double knockout
• 刊名：Peptides
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：88
• 期：Complete
• 页码：1-7
• 全文大小：1547 K
• 卷排序：88

文摘

Ramp1−/− male mice have higher basal blood pressure while under anesthesia. Ramp1−/−, Ramp3−/−, and Calcrl+/− males have higher basal blood pressure than females. Hypotension via bolus infusion of AM or CGRP is attenuated in Ramp1−/− mice. Some AM-induced hypotension is attenuated in Ramp3−/− and Calcrl+/− mice.