TRPV3 channels mediate Ca2+ influx induced by 2-APB in mouse eggs
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- 作者：Hoi Chang Leea ; Sook-Young Yoonb ; Karin Lykke-Hartmannc ; d ; e ; Rafael A. Fissorea ; rfissore@vasci.umass.edu" class="auth_mail" title="E-mail the corresponding author ; Ingrid Carvachoc ; e ; icarvacho@biomed.au.dk" class="auth_mail" title="E-mail the corresponding author
- 关键词：TRPV3 ; transient receptor potential ; subfamily Vanilloid ; member 3 ; 2-APB ; 2-aminoethoxydiphenyl borate ; MII ; metaphase II of the second meiosis ; IP3R ; inositol 1 ; 4 ; 5-trisphosphate receptor ; PM ; plasma membrane ; SERCA ; Sarco/endoplasmic reticulum Ca2+-ATPase ; STIM ; stromal interaction molecule ; SOCE ; store-operated Ca2+ entry ; CRAC ; calcium release-activated calcium ; GV ; germinal vesicle ; PN ; pronucleus ; PLCζ ; phospholipase zeta ; MPF ; maturation-promoting factor ; RFP ; ruby fluorescent protein ; I
- 刊名：Cell Calcium
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：59
- 期：1
- 页码：21-31
- 全文大小：2336 K
文摘
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Expression of TRPV3 channels can be regulated by dsRNA injection in GV oocytes.
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Overexpressed RFP-TRPV3 protein localizes to the plasma membrane of mouse oocytes.
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2-APB mediates Ca2+ influx through TRPV3 channels.
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Protein synthesis regulates the response to 2-APB in oocytes.
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Altering the actin cytoskeleton affects TRPV3 function and/or distribution.