Urotensin II induction of neonatal cardiomyocyte hypertrophy involves the CaMKII/PLN/SERCA 2a signaling pathway
详细信息 查看全文
- 作者：Hongtao Shia ; Qinghua Hana ; biohanqinghua@sohu.com" class="auth_mail" title="E-mail the corresponding author ; Jianrong Xua ; Wenyuan Liua ; Tingting Chub ; Li Zhaoa
- 关键词：UII ; Urotensin II ; CaMKII ; calcium/calmodulin-dependent protein kinase II ; UT ; urotensin receptor ; SR ; sarcoplasmic reticulum ; SERCAs ; serco/endo-plasmic reticulum ATPases ; ECC ; excitation&ndash ; contraction coupling ; DMEM ; Dulbecco's modified Eagle's medium ; EGFR ; epidermal growth factor receptor
- 刊名：Gene
- 出版年：2016
- 出版时间：25 May 2016
- 年：2016
- 卷：583
- 期：1
- 页码：8-14
- 全文大小：1069 K
文摘
- •
UII increases cardiomyocyte size, protein/DNA ratio and intracellular Ca2 +, consistent with a hypertrophic response.
- •
UII upregulates the phosphorylation of CaMKII and its downstream target PLN (Thr17), SERCA 2a levels.
- •
UII induces cardiomyocyte hypertrophy through CaMKII-mediated up-regulating of PLN Thr17–phosphorylation signaling pathway.