Accelerated DNA methylation age: Associations with PTSD and neural integrity
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- 作者：Erika J. Wolfa ; b ; erika.wolf@va.gov" class="auth_mail" title="E-mail the corresponding author ; Mark W. Loguec ; d ; e ; Jasmeet P. Hayesa ; b ; g ; Naomi Sadeha ; b ; Steven A. Schichmanf ; Annjanette Stonef ; David H. Salatg ; William Milbergh ; i ; Regina McGlincheyh ; i ; Mark W. Millera ; b
- 关键词：Accelerated aging ; DNA methylation ; PTSD ; Diffusion tensor imaging ; Genu ; Working memory
- 刊名：Psychoneuroendocrinology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：63
- 期：Complete
- 页码：155-162
- 全文大小：745 K
文摘
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Cellular age can be indexed by DNA methylation and may be advanced relative to chronological age due to environmental factors.
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Among 281 Iraq/Afghanistan veterans, we found PTSD severity to be associated with accelerated DNA methylation age.
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Accelerated DNA methylation age was also associated with reduced neural integrity in the genu of the corpus callosum.
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Accelerated DNA methylation age was indirectly linked to poorer working memory via reduced integrity of the genu.
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This highlights the clinical significance of PTSD-related accelerated aging with respect to neural integrity and cognition.