Identification of peptides in wheat germ hydrolysate that demonstrate calmodulin-dependent protein kinase II inhibitory activity
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- 作者：Thanutchaporn Kumrungsee ; Sayaka Akiyama ; Jian Guo ; Mitsuru Tanaka ; Toshiro Matsui ; tmatsui@agr.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Wheat germ ; Peptides ; Calmodulin-dependent protein kinase II ; Thermolysin
- 刊名：Food Chemistry
- 出版年：2016
- 出版时间：15 December 2016
- 年：2016
- 卷：213
- 期：Complete
- 页码：329-335
- 全文大小：841 K
文摘
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Wheat germ hydrolyzed by thermolysin inhibited in vitro CaMK II activity.
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Trp-Val and Trp-Ile were identified as CaMK II inhibitor.
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The N-terminal Trp residue is essential for the inhibitory effect.
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Trp-Val and Trp-Ile inhibited the binding of the Ca2+-CaM complex to CaMK II.