Clinical features of Japanese polycythemia vera and essential thrombocythemia patients harboring CALR, JAK2V617F, JAK2Ex12del, and MPLW515L/K mutations
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- 作者：Masahiro Okabea ; 1 ; Hiroki Yamaguchia ; 1 ; y-hiroki@fd6.so-net.ne.jp" class="auth_mail" title="E-mail the corresponding author ; Kensuke Usukib ; Yutaka Kobayashic ; Eri Kawatac ; Junya Kurodad ; Shinya Kimurae ; Kenji Tajikaf ; Seiji Gomif ; Nobuyoshi Arimag ; Sinichiro Morih ; Shigeki Itoi ; Masayuki Koizumij ; Yoshikazu Itok ; Satoshi Wakitaa ; Kunihito Araia ; Tomoaki Kitanoa ; Fumiko Kosakaa ; Kazuo Dana ; Koiti Inokuchia
- 关键词：Polycythemia vera ; Essential thrombocythemia ; JAK2 mutation ; MPL mutation ; CALR mutation
- 刊名：Leukemia Research
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：40
- 期：Complete
- 页码：68-76
- 全文大小：1900 K
文摘
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We assessed the clinical features and genetic mutations of Japanese MPN patients.
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The clinical features of JAK2V617F and CALR mutation ET differ.
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We did not find a correlation between CALR mutations and the 46/1 haplotype.
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CALR mutation ET had a lower incidence of thrombosis relative to JAK2V617F ET.