Myeloproliferative neoplasms: Current molecular biology and genetics
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- 作者：Kolsoum Saeidi kolsoum.saeidi@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Myeloproliferative neoplasms ; Polycythemia vera ; JAK2 ; CALR
- 刊名：Critical Reviews in Oncology and Hematology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：98
- 期：Complete
- 页码：375-389
- 全文大小：2320 K
文摘
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Current molecular biology and genetic mechanisms involved in MNPs are discussed.
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Impact of JAK2V617F mutation as a diagnostic marker with a high frequency on MPN subgroup is described.
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Impact of CALR mutations in MF and ET patients is addressed.
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Favorable impact of type 1/type 1-like CALR mutations and unfavorable impact of ASXL1 mutations in PMF cases are discussed.
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Genes involved in chromatin methylation and modifications are associated with MPNs.