Characterization of CD34+ hematopoietic progenitor cells in JAK2V617F and CALR-mutated myeloproliferative neoplasms
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- 作者：Anna Angonaa ; c ; e ; Alberto Alvarez-Larrá ; na ; c ; e ; 95967@parcdesalutmar.cat" class="auth_mail" title="E-mail the corresponding author ; Beatriz Bellosillob ; d ; e ; Raquel Longaró ; nb ; e ; Laura Camachob ; e ; M. Concepció ; n Ferná ; ndez-Rodrí ; guezb ; e ; Silvia Pairetb ; e ; Carles Bessesa ; e
- 关键词：Myeloproliferative neoplasms ; JAK2V617F ; CALR ; Allele burden ; Hematopoietic stem cells
- 刊名：Leukemia Research
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：48
- 期：Complete
- 页码：11-15
- 全文大小：751 K
文摘
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CALR-mutated ET patients harbored a higher mutant load at progenitor level than JAK2-positive ET.
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Hematopoietic stem cells of CALR-mutated ET showed a similar mutational load than CALR-mutated MF.
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The mutated clone size in chronic phase of MPN is different according to genotype.